Prior to ACUP approval, investigators must demonstrate they actively searched for alternatives to procedures that may cause animal pain or distress. To answer Q. 11a and 11b of the AUP form, include:
Questions about the search process or these requirements? Contact Elizabeth Salmon (email@example.com), Research Services Librarian.
The Animal Welfare Act (AWA) requires principal investigators to consider alternatives to procedures that may cause more than momentary or slight pain or distress to animals and provide a written narrative of the methods used and sources consulted to determine the availability of alternatives, including refinements, reductions, and replacements (the 3 Rs).
Conducting a literature search is the primary method of meeting this requirement. Policy 12 of the The USDA's Animal Care Policy Manual outlines the requirements for conducting and reporting the results of a comprehensive literature search.
By examining the literature, you may discover that other laboratories have already worked on certain parts of your research project, making a duplicate experiment unnecessary. You may also discover alternative methods of animal care, animal treatment, or experimental design that require fewer or less expensive specimens.
Locating animal or procedural alternatives is integral to replacement, reduction and/or refinement to minimize animal pain and distress, consistent with research goals.
Before conducting your search, it is necessary to determine which procedures in the protocol have the potential to cause pain or distress.
This is not always a straightforward process; these resources can be a starting point for making those determinations.
Consult UC Merced Attending Veterinarian: Katherine Wasson Clark, DVM, PhD